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P1 blood group antigen expression and epidemic hemolytic uremic syndrome |
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| Authors: | Pamela H. Orr Victor Dong Marlis L. Schroeder Malcolm R. Ogborn |
| Affiliation: | (1) Department of Community Health Sciences, University of Manitoba, Manitoba, Canada;(2) Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada;(3) Canadian Red Cross Blood Transfusion Service, Winnipeg, Manitoba, Canada;(4) AE102-840, Sherbrook St, R3A 1S1 Winnipeg, Manitoba, Canada |
| Abstract: | P1 blood group positivity has been postulated as a host factor which may provide protection against the development of post-enteropathic hemolytic uremic syndrome (HUS). In this study, blood group status in 20 Inuit survivors ofEscherichia coli 0157: H7-associated HUS was compared with age-and sex-matched controls from the same community who had experienced uncomplicated diarrheal illness due to the same pathogen. Of 20 HUS survivors, 6 were P1 antigen positive compared with 8 of the 20 controls (P=0.7). We conclude that P1 antigen positivity was not protective against HUS in this population. Further studies of this condition to clarify the role of host factors in verotoxin-induced endothelial damage are indicated. |
| Keywords: | Blood group P1 Hemolytic uremic syndrome Escherichia coli 0157:H7 Verotoxin Inuit |
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