| 肺移植术后血清HMGB1水平的变化及其临床意义 |
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| 引用本文： | 王发龙,陈静瑜,胡志刚,陈国千.肺移植术后血清HMGB1水平的变化及其临床意义[J].中国实验诊断学,2011,15(11):1857-1858. |
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| 作者姓名： | 王发龙 陈静瑜 胡志刚 陈国千 |
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| 作者单位： | 1. 南京医科大学附属无锡人民医院,医学检验科,江苏,无锡,214023
2. 南京医科大学附属无锡人民医院,胸外科 |
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| 摘 要： | 目的探讨血清高迁移率族蛋白B1（HMGB1）水平在肺移植术后的变化和临床意义。方法肺移植21例,其中术后稳定者10例、术后发生急性排斥反应5例、肺部感染6例。采用酶联免疫吸附试验（ELISA）对19名健康者和肺移植患者术前、术后第1、3、7天的血清HMGB1水平进行检测。结果肺移植术后患者血清HMGB1水平明显升高,急性排斥反应组术后第7天血清HMGB1水平明显高于稳定组（P〈0.01）,肺部感染组术后第3天和术后第7天的血清HMGB1水平均明显高于稳定组和急性排斥反应组。健康对照组血清HMGB1水平明显低于肺移植患者术前水平（P〈0.01）。结论肺移植术后血清HMGB1水平升高,血清HMGB1检测对肺移植术后并发症诊断有较好价值。
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| 关 键 词： | 高迁移率族蛋白B1 肺移植 血清 |
Clinical significance of serum HMGB1 determination after lung transplantation |
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| WANG Fa-long,CHEN Jing-yu,Hu Zhi-gang,et al..Clinical significance of serum HMGB1 determination after lung transplantation[J].Chinese Journal of Laboratory Diagnosis,2011,15(11):1857-1858. |
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| Authors: | WANG Fa-long CHEN Jing-yu Hu Zhi-gang |
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| Institution: | WANG Fa-long,CHEN Jing-yu,Hu Zhi-gang,et al.(Department of Clinical Laboratory,Wuxi People's Hospital Affiliated to NJMU,Wuxi 214023,China) |
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| Abstract: | Objective To investigate the change of serum HMGB1 level after lung transplantation and its clinical significance.Methods 21 patients were divided into stable group(n=10),acute rejection group(n=5) and infected group(n=6) according to the complications after lung transplantation.Serum HMGB1 level was determinated in 19 healthy cases and 21 patients at the preoperative day,1st day,3rd day and 7th day after lung transplantation by ELISA.Results Serum HMGB1 level was markedly increased after lung transplantati... |
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| Keywords: | high mobility group box 1 lung transplantation serum |
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