| IL-6干预对3T3-L1脂肪细胞SAA表达的影响 |
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| 引用本文： | 戴永利,叶夏云,葛秀洁,王君霞.IL-6干预对3T3-L1脂肪细胞SAA表达的影响[J].军医进修学院学报,2010,31(5):475-476. |
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| 作者姓名： | 戴永利 叶夏云 葛秀洁 王君霞 |
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| 作者单位： | 1. 兰州军区兰州总医院小儿科,甘肃兰州,730050
2. 兰州军区兰州总医院内分泌科,甘肃兰州,730050 |
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| 摘 要： | 目的观察IL-6干预对3T3-L1脂肪细胞血清淀粉样蛋白A（SAA）表达的影响。方法用不同浓度IL-6（0.1ng/ml,1ng/ml,10ng/ml）处理3T3-L1脂肪细胞24h、10ng/mlIL-6处理不同时间（6h、12h、24h）,用ELISA技术检测各组SAA的表达。结果TNF-a能显著促进3T3-L1脂肪细胞SAA的表达,并呈剂量和时间依赖方式。结论IL-6可以通过促进3T3-L1脂肪细胞SAA的表达和分泌,参与胰岛素抵抗及血管并发症的形成。
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| 关 键 词： | IL-6 3T3-L1脂肪细胞 血清淀粉样蛋白A |
Effect of IL-6 intervention on expressions of SAA in 3T3-L1 adipocytes |
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| DAI Yong-li,YE Xia-yun,GE Xiu-jie,WANG Jun-xia.Effect of IL-6 intervention on expressions of SAA in 3T3-L1 adipocytes[J].Academic Journal of Pla Postgraduate Medical School,2010,31(5):475-476. |
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| Authors: | DAI Yong-li YE Xia-yun GE Xiu-jie WANG Jun-xia |
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| Institution: | DAI Yong-li1,YE Xia-yun2,GE Xiu-jie2,WANG Jun-xia1 1Department of Pediatrics,2Department of Endocrinology General Hospital of Lanzhou Military Area Comm,,Lanzhou 730050,Gansu Province,China |
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| Abstract: | Objective To investigate the effect of IL-6 intervention on SAA expression in 3T3-L1 adipocytes.Methods 3T3-L1 adipocytes were incubated with IL-6 at different concentrations(0.1ng/ml,1ng/ml,10ng/ml)for different periods of time(6,12 and 24h).SAA expression in different groups was detected by ELISA.Results IL-6 significantly increased the expression of SAA in 3T3-L1 adipocytes in a dose-and time-dependent manner.Conclusion IL-6 participates in insulin resistance and formation of vascular complication by sti... |
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| Keywords: | Interliukin-6 3T3-L1 Fat Cells Serum Amyloid A Protein |
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