补充牛磺酸对正常大鼠脂代谢的影响

为研究不同牛磺酸水平对正常大鼠血脂的影响 ,将 40只断乳SD大鼠用基础饲料喂养一周后 ,按体重和血浆总胆固醇均衡的原则分为 4组 ,对照组进食正常饲料 ,其余 3组分别在基础饲料的基础上添加不同水平 (6、1.35和 3g kg饲料 )的牛磺酸 ;实验 5周后 ,观察牛磺酸对大鼠血脂的影响。结果表明 ,与正常对照组相比 ,不同剂量的牛磺酸均可显著影响大鼠血浆脂质水平 ;6g kg牛磺酸降低血清总胆固醇、低密度脂蛋白胆固醇效果最明显 ,13.5g kg牛磺酸可显著降低血清甘油三酯、载脂蛋白 B水平 ,促进粪胆汁酸排泄 ;30g kg牛磺酸对降低大鼠肝脏总胆固醇、升高血清载脂蛋白效果较好。

Effect of taurine on blood and liver lipids in rats

The effect of taurine on serum and liver cholesterol level in rats and its mechanism was investigated. Female weanling SD strain rats (80-100 g) were divided into four groups, eight rats in each group. Group A fed with normal diet. The diet of groups B, C and D was normal diet incorporated with taurine at the levels of 6, 13.5 and 30 g/kg diet respectively. The experiment lasted for five weeks. Results showed that the blood cholesterol levels of rats with diets containing taurine were decreased. The decrease of plasma total cholesterol(TC), low density lipoprotein-cholesterol in the 6 g/kg taurine group was the most significant. Plasma triglycerides and apolipoprotein(Apo)-B in the 13.5 g/kg taurine group was decreased, and the amount of fecal bile acids was increased in this group. Plasma Apo-AI of the 30 g/kg taurine group was increased and the liver TC was decreased.