原发性甲亢自身抗体测定与术后临床转归的关系

目的 探讨原发性甲亢患者手术前后自身抗体及细胞学的变化与术后甲状腺功能的关系。方法对３０例原发甲亢患者，术前测定甲状腺激素及抗甲状腺球蛋白抗体（ＴＧＡ）、抗甲状腺微粒体抗体（ＴＭＡ），观察甲状腺内淋巴细胞浸润程度。术后随访１年，再次测定，甲状腺功能示恢复正常４者用针吸活组织检查法对残留甲状腺行淋巴细胞浸润程度分析。结果 术前，１０例患者出现明显淋巴细胞浸润及ＴＧＡ、ＴＭＡ明显升高，１６例仅出现淋马

RELATIONSHIP BETWEEN AUTOANTIBODY AND CLINICAL PROGNOSIS FOR PRIMARY HYPERTHYROIDISM

ObjectiveTo investigate the relationship between pre-and post-operative autoantibody , cellulous changes and postoperative thyroid function for primary hyperthyroid patients. MethodsMeasurement of serum thyroxine ,autoantibody(TGA,TMA) and analysis of lymphocyte infiltration degree in thyroid glands were performed in thirty patients with hyperthyroidism.Followed up for one year after operation,these patients were monitored of the above parameters again, infiltration degree of lymphocyte in the remnant of thyroid glands were analysed with needle biopsy for malfunction patients. ResultsBefore operation, significant infiltration of lymphocyte and increase of TGA,TMA were observed in 10 patients, while only infiltration of lymphocyte in 16 patients, there were no significant changes of the above parameters in the rest.One year after operation, twenty-three patients recovered, three reoccurred with hyperthyroidism ,four occurred with hypothyroidism.There were TGA,TMA positive expression and significant infiltration of lymphocyte in five patients with thyroid malfunction. ConclusionThe relationship between postoperative thyroid function and changes of autoantibody as well as infiltration degree of lymphocyte is very close for primary hyperthyroidism.