2型糖尿病患者IMT、FFA水平变化及临床意义

目的探讨2型糖尿病患者颈动脉内膜中层厚度（IMT）与游离脂肪酸（FFA）水平变化及临床意义。方法选取63例2型糖尿病患者，另选取60例同期健康体检者，分为A、B两组，A组为2型糖尿病组，B组为健康对照组。比较两组血清游离脂肪酸、颈动脉内膜中层厚度以及血糖血脂水平。结果2型糖尿病组血清FFA水平为（562．68±58．54）μmol／L，IMT为（1．10±0．23）mm，明显高于健康对照组（354．23±45．87）μmol／L，（0．69±0．12）mm，P均〈0．05，差异具有统计学意义；2型糖尿病组空腹血糖水平为（10．80±2．99）mmol／L，明显高于健康对照组（4．74±0．90）mmol／L（P〈0．05），且A组TC、TG、LDL、HDL水平较B组均有升高（P〈0．05）。结论2型糖尿病患者血清游离脂肪酸水平升高与颈动脉内膜中层增厚相关。

The level change and clinical significance of FFA and IMT in type 2 diabetes

Objective To explore the level change and clinical significance of FFA and IMT in type 2 diabetes. Methods Serum level of FFA, carotid IMT, the level of serum lipid and blood glucose were detected in 63 type 2 diabetes mellitus patients （Group A） and 60 healthy controls （Group B）. Results In the type 2 diabetes mellitus group, serum levels of FFA and IMT were, （562.68±58.54） μmol/L and （1.10±0.23）mm, respectively, which were higher than those in healthy control group （354.23±45.87） μmol/L and （0.69＋0.12） mm respectively, with significantly difference （P 〈 0.05）. The level of serum glucose in type 2 diabetes mellitus group was （10.80±2.99） mmol/L, which is higher than it in healthy control group （4.74±0.90）mmol/L （P 〈 0.05）. And there was significant difference between Group A and Group B in the levels of TC, TG, LDL, HDL （P 〈 0.05）. Conelusion Serum level of FFA is associated with IMT in type 2 diabetes mellitus.