顺铂联合重组人白介素-2治疗乳腺癌胸腔积液的临床观察 |
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引用本文: | 陆鹏,杨铁建,王林梅.顺铂联合重组人白介素-2治疗乳腺癌胸腔积液的临床观察[J].中国现代医生,2012(36):54-55. |
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作者姓名: | 陆鹏 杨铁建 王林梅 |
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作者单位: | [1]郑州人民医院肿瘤外科,河南郑州450003 [2]郑州大学第二附属医院呼吸内科,河南郑州450014 |
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摘 要: | 目的观察胸腔注射白介素-2(IL-2)和顺铂+IL-2分别治疗乳腺癌恶性胸腔积液的疗效。方法50例乳腺癌伴恶性胸腔积液患者置入胸腹腔引流管(16F),充分引流出胸水后随机分成两组:IL-2组:50万IU/次,每周2次,连用2周:顺铂+IL-2组:顺铂40mg/m2+IL-250万IU,2次/周,连用2周。结果顺铂+IL-2组有效率92.6%,明显高于IL-2组的43.5%(P〈0.01)。顺铂+IL-2组胃肠道不适较IL-2组明显。结论顺铂联合lL-2胸腔灌注治疗乳腺癌恶性胸腔积液疗效满意.不良反应可耐受。
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关 键 词: | 顺铂 白介素-2 乳腺癌 恶性胸腔积液 |
Treatment of malignant pleural effusion by breast cancer using IL-2 and cisplatine intrapleurally injection |
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Authors: | LU Peng YANG Tiejian WANG Linmei |
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Institution: | 1.Tumor Surgery, Zhengzhou People's Hospital, Zhengzhou 450003, China; 2.Department Respiratory, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China) |
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Abstract: | Objective To evaluate the efficacy of treating malignant pleural effusion of breast cancer with cisplatine and IL-2 by injection through thoracic tube intubation. Methods Fifty cases with malignant pleural effusion of breast cancer, after drainage,randomly divided into two groups. IL-2 50 IU, cisplatine 40 mg/rn2 were injectred into pleural cavity in cis- platine plus IL-2 group (group I ), and only IL-2 50 IU in IL-2 group (group II ),2 times per week for 2 consecutive weeks. Results The efficiency in the two groups was respectively 92.6%(group I ), 43.5%(group 11 ). The efficiency in group I was higher than that in group I1 with significant differences (P 〈 0.01). The gastrointestinal discomfort is more obvious in group I than group I]. Conclusion Anocelia perfusion with cisplatin and IL - 2 had good effect on malignant pleural effusion of breast cancer and the adverse reaction can be tolerated. |
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Keywords: | Cisplatine IL-2 Breast cancer Malignant pleural effusion |
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