Prevalence of Glaucoma in Adults with Down's Syndrome |
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| Authors: | Tomoko Yokoyama Hiroki Tamura Hidetoshi Tsukamoto Kiyoko Yamane Hiromu K. Mishima |
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| Affiliation: | (1) Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan;(2) Department of Pediatrics, Hiroshima Child Guidance Center for Mental and Physical Disabilities, Hiroshima, Japan;(3) Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan |
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| Abstract: | Purpose To compare the prevalence of glaucoma in adults with Down's syndrome (DS) to that in non-DS control adults. Methods Twenty-six patients (14 men and 12 women) with DS and 188 control subjects (105 men and 83 women) were studied. The mean age was 35.1 ± 6.9 (± SD) years in the DS group and 36.9 ± 5.2 years in the control group. There were no significant differences in age or sex distribution between the two groups. Glaucoma was diagnosed by two glaucoma specialists based on the optic disc findings obtained through dilated pupils. Results The prevalence of patients with glaucoma in the DS group was 11.5%, significantly higher (P = 0.014) than that in the control group, 1.1%. There was no significant difference in intraocular pressure between glaucomatous eyes (12.2 ± 3.2?mmHg) and nonglaucomatous eyes (11.1 ± 4.1?mmHg) in the DS group (P = 0.465). Conclusions The prevalence of glaucoma in adult patients with DS was significantly higher than that in age-matched control subjects.?Jpn J Ophthalmol 2006;50:274–276 © Japanese Ophthalmological Society 2006 |
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| Keywords: | Down's syndrome glaucoma neurodegenerative disease prevalence |
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