翼状胬肉切除联合自体角膜缘干细胞移植术疗效观察

目的 回顾性分析58例（98只患眼）翼状胬肉患者，探讨翼状胬肉单纯切除术与翼状胬肉切除联合自体角膜缘干细胞移植术治疗翼状胬肉的临床疗效。方法 2003年3月至2005年12月，对30例（45只患眼）翼状胬肉患者行翼状胬肉单纯切除术，2006年5月至2007年5月，对28例（43只患眼）翼状胬肉患者行翼状胬肉切除联合自体角膜缘干细胞移植术，观察术后角膜上皮修复、翼状胬肉复发情况。结果 术后随访观察6～18个月，翼状胬肉单纯切除组有15只患眼复发（33．3％），角膜上皮恢复时间为4～7d，平均5．8d，联合角膜缘干细胞移植组1只患眼复发（2．3％），角膜上皮恢复时间为2～4d，平均2．6d，二者比较差异有统计学意义（P〈0．05）。结论 翼状胬肉切除联合自体角膜缘干细胞移植术能有效阻止胬肉复发，并且促进术区角膜上皮修复，是治疗翼状胬肉的理想手术方法。

Clinical observation of pterygium excision with limbal stem cell autograft transplantation for treatment of pterygium

Objective To analyze 58 cases(98 eyes)of pterygium by operative treatment in our hospital and to explore the curative effect of pterygium excision with limbal stem cell autograft transplantation for treatment of pterygium.Methods Between March 2003 and December 2005,30 cases(45 eyes)of pterygium were cured by simple pterygium excision.Between May 2006 and May 2007,28 cases(43 eyes)of pterygium were cured by pterygium excision with limbal stem cell autograft transplantation.The general situation of recover of corneal epithelium and the recurrence of pterygiun were observed after surgery.Results All cases were followed up for 6-18 months.15 eyes recurred(recurrent rate was 33.3%)and corneal epithelium were recovered with 4-7 days(mean 5.8 days)in simple pterygium excision group.One eye recurred(recurrent rate was 2.3%)and corneal epithelium were recovered with 2-4 days(mean 2.6 days)in pterygium excision with limbal stem cell autograft transplantation group.The differences were significant between the two group(P<0.05).Conclusion Pterygium excision with limbal stem cell autograft transplantation for treatment of pterygium is effectively prevent the recurrence of pterygiun and expedite the recover of corneal epithelium.It is the ideal surgical method of pterygium therapy.