慢性重型乙型肝炎与HLA-DRB1基因多态性的相关性研究

目的 探讨慢性重型乙型肝炎患者与HLA-DRB1基因多态性的相关性.方法 采用聚合酶链反应,序列特异性引物技术对河南地区26例慢性重型乙型肝炎患者和45例健康对照者进行HLA-DRB1等位基因的检测,应用统计学软件SPSS13.0对两组实验结果进行X2检验.结果 在慢性重型乙型肝炎组中,HLA-DRB1*1301/1302出现的频率明显高于对照组,差异有统计学意义;HLADRB1*150111502,*1201/1202在两组间出现的频率相比差异无统计学意义.结论 HLA-DRB1*1301/1302等位基因可能和慢性重型肝炎的发生有关,HLA-DRB1*1501/1502,*1201/1202与慢性重型肝炎的发生无相关性.

Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism

Objecttve To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.Methods 26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique.The results were compared with those from 45 normal healthy people by use of X2-test of Microsoft SPSS 13.0.Results The frequency of HLADRB1*1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group,while the frequencies of HLA-DRB1*1201/1202,1501/1502 allele were not significantly different.Conclusion HLA-DRB1*1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B,While HLA-DRB1*1201/1202,1501/1502 have no association with severe chronic hepatitis B.