Age-related macular disease in a 91-year-old patient: Histologic findings

Age-related macular degeneration in the eye of a 91-year-old man was studied histologically. Typical of this disease, which manifests as death of central photoreceptors, were dystrophic changes of the retinal pigment epithelium (RPE) and neural retina. Also typical were increased drusen deposits, which accumulated between the RPE basement membrane and the inner layer of Bruch's membrane, and choroidal neovascularization. We histologically observed and demonstrated a subclinical neovascularization that fluorescein angiography did not.