氨氯地平联合阿托伐他汀对高血压合并原发性高血脂的临床治疗作用观察

目的:观察氨氯地平联合阿托伐他汀治疗高血压伴高血脂的疗效。方法:76例高血压伴原发性高血脂患者随机分为2组,试验组39例,每日服用氨氯地平及阿托伐他汀;对照组37例服用氨氯地平。治疗16周后,观察每组患者血压、血脂、血清C反应蛋白及左心室重量指数情况。结果:治疗16周后,2组患者血压及左心重量指数均降低(p<0.05),而试验组患者的血压及左心重量指数明显低于对照组患者血压(p<0.05);试验组患者血脂及血清C反应蛋白小于对照组(p<0.05),而高密度脂蛋白高于对照组(p<0.05)。结论:氨氯地平联合阿托伐他汀联合治疗能明显降低血压,并逆转左心室重建,临床可供治疗高血压合并高血脂患者。

The Combination of Amlodipine and Atorvastatin for Treating Patients with Hypertension and Hyperlipemia

Objective：To investigate the therapeutic effect of the combination of atorvastatin and amlodipine in hypertensive patients with primary high lipids.Methods： 76 hypertensive patients with primary high lipids were divided into two groups randomly;39 patients in the test group were treated with amlodipine plus atorvastatin,and other patients in the control group were treated with amlodipine only;all patients were treated for 16 weeks of We measured blood pressure,blood-lipid,C-reactive protein（CRP） and left ventricular mass index（LVMI）.Results： After 16 weeks of treatment,blood pressure and LVMI were reduced in both groups（p0.05）,but the indicators in the test group were significantly lower than those in the control group（p0.05）;Meanwhile,blood-lipid and CRP in the test group were lower than those in control group（p0.05）,and the serum concentration of high-density lipoprotein cholesterol in the test group was higher（p0.05）.Conclusion： The combination of amlodipine-atorvastatin remarkablely reduced the blood pressure and reversed left ventricular remodeling,compared with amlodipine therapy.The combination of amlodipine and atorvastatin could be a good choice of the treatment in hypertensive patients with hypercholesterolemia in the clinical setting.