| 河南林州市居民贲门癌组织的比较基因组杂交分析 |
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| 引用本文： | 秦艳茹,王立东,庄则豪,安继业,范宗民,高珊珊,郭花芹. 河南林州市居民贲门癌组织的比较基因组杂交分析[J]. 郑州大学学报(医学版), 2002, 37(6): 742-745 |
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| 作者姓名： | 秦艳茹 王立东 庄则豪 安继业 范宗民 高珊珊 郭花芹 |
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| 作者单位： | 1. 郑州大学医学院癌症研究室,郑州,450052
2. 郑州大学医学院癌症研究室,郑州,450052;福建医科大学第一附属医院消化内科,福州,350005 |
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| 基金项目： | 国家杰出青年科学基金 3 0 0 2 5 0 16，河南省高校创新人才工程基金，河南省医药卫生创新人才工程基金资助项目 |
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| 摘 要： | 目的：探讨贲门癌高发区河南林州市贲门癌组织中的基因组变化，寻找相关未知基因。方法：采用比较基因组杂交的方法（comparative genomic hybridization,CGH)分析10例原发性贲门癌组织基因组变化。结果；CGH分析显示1q(4/10),11q(3/10),3q(2/10),8q(3/10),8p(2/10)为出现频率较高的扩增区，9q(3/10)的缺失可能是贲门癌的特征性变化。结论：1q,11q,3q,8q,8p,9q可能存在与贲门癌相关的未知基因。
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| 关 键 词： | 河南 林州市 居民 贲门癌 比较基因组杂交 |
| 修稿时间： | 2002-06-10 |
Comparative genomic hybridization analysis on primary gastric cardia ad-enocarcinomas from the patients at Linzhou, Henan |
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| QIN Yanru ),WANG Lidong ),ZHUANG Zehao ,),AN Jiye ),FAN Zongmin ),GAO Shanshan ),GUO Huaqin ) )Labortory for Cancer Research,College of Medcine,Zhengzhou University,Zhengzhou ). Comparative genomic hybridization analysis on primary gastric cardia ad-enocarcinomas from the patients at Linzhou, Henan[J]. Journal of Zhengzhou University: Med Sci, 2002, 37(6): 742-745 |
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| Authors: | QIN Yanru ) WANG Lidong ) ZHUANG Zehao ) AN Jiye ) FAN Zongmin ) GAO Shanshan ) GUO Huaqin ) )Labortory for Cancer Research College of Medcine Zhengzhou University Zhengzhou ) |
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| Affiliation: | QIN Yanru 1),WANG Lidong 1),ZHUANG Zehao 1,2),AN Jiye 1),FAN Zongmin 1),GAO Shanshan 1),GUO Huaqin 1) 1)Labortory for Cancer Research,College of Medcine,Zhengzhou University,Zhengzhou 450052 2)Department of Gastroenterology,the First Affiliated Hospital,Fujian Medical University,Fuzhou 350005 |
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| Abstract: | Aim: To explore the genomic changes in gastric cardia adenocarcinomas (GCA) from the patients at high incidence area for GCA in Henan, and to screen new genes related with GCA. Methods: Comparative genomic hybridization (CGH) was applied with 10 cases of GCA to analyze the genomic changes in GCA. Results: CGH analysis showed that there was a high frequency of gene amplification at chromosomes 1q(4/10), 11q(3/10), 3q(2/10),8q(3/10), 8p(2/10). A loss of 9q(3/10) was frequently observed.Conclusion: There may be some unknown genes located in the regions of chromosomes 1q,11q,3q,8q,8p,9q,which may be of importance to GCA. |
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| Keywords: | gastric cardia adenocarcinoma comparative genomic hybridization chromosome |
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