| 狼疮性肾炎病人血浆内皮素的变化及意义 |
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| 引用本文： | 万美燕,腊岩,马小莉. 狼疮性肾炎病人血浆内皮素的变化及意义[J]. 齐鲁医学杂志, 1999, 14(2) |
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| 作者姓名： | 万美燕 腊岩 马小莉 |
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| 作者单位： | 青岛市市立医院肾内科,青岛,266011 |
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| 摘 要： | 目的探讨狼疮性肾炎（ＬＮ）病人血浆内皮素的变化及意义。②方法采用放射免疫分析法，对２０例正常人和２７例ＬＮ病人的血浆内皮素（ＥＴ－１）含量进行了测定。③结果ＬＮ病人血浆ＥＴ－１水平高于正常人，而伴有肾功能损害和高血压的ＬＮ病人血浆ＥＴ－１水平高于ＬＮ组和正常人（Ｆ＝５．２８，ｑ＝７．５６～１１．１０，Ｐ＜０．０５）。ＬＮ病人血浆ＥＴ－１水平与血尿素氮、肌酐呈正相关（ｒ＝０．４１２，０．５０８，Ｐ＜０．０５），与内生肌酐清除率呈负相关（ｒ＝－０．６７２，Ｐ＜０．０５）。④结论ＬＮ病人血浆ＥＴ－１水平升高与肾功能损害和高血压及肾脏免疫损伤有关。
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| 关 键 词： | 狼疮肾炎 内皮缩血管肽类 肾功能试验 |
THE CHANGES OF ENDOTHELIN IN PATIENTS WITH LUPUS NEPHRITIS AND ITS CLINICAL SIGNIFICANCES |
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| Wan Meiyan,La Yan,Ma Xiaoli. THE CHANGES OF ENDOTHELIN IN PATIENTS WITH LUPUS NEPHRITIS AND ITS CLINICAL SIGNIFICANCES[J]. Medical Journal of Qilu, 1999, 14(2) |
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| Authors: | Wan Meiyan La Yan Ma Xiaoli |
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| Abstract: | Objective To explore the changes of endothelin(ET 1) in patients with lupus nephritis( LN) and its clinical significances. Methods The changes of ET 1 was measured in 20 patients with LN and 27 controls by using radioimmunologic assay. Results The ET 1 was significantly higher in LN patients than those in controls, and the ET 1 was significantly higher in the group with renal function damage and hypertension ( F=5.28, q=7.56-11.10,P <0.05). In LN patients,the level of ET 1 was positively correlated with plasma urea nitrogen and creatinine( r= 0.412,0.508, P <0.05), and negtively correlated with the intrinsic creatinine clearance rate ( r=-0.672,P <0.05). Conclusion The level of ET 1 was correlated with the injury of renal function, hypertension and the immune injury of kidney. |
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| Keywords: | lupus nephritis endothelin kidney function tests |
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