Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients |
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Authors: | Costa Paola Rusconi Stefano Fogli Manuela Mavilio Domenico Murdaca Giuseppe Puppo Francesco Mingari Maria Cristina Galli Massimo Moretta Lorenzo De Maria Andrea |
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Affiliation: | Dipartimento di Medicina Interna, University of Genova, Genoa, Italy. |
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Abstract: | We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mononuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients. |
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