| 应用微卫星多态标记进行大肠癌中5q21-q22杂合性丢失的初步研究 |
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| 引用本文： | 王筠,张学,郝冬梅,孙开来. 应用微卫星多态标记进行大肠癌中5q21-q22杂合性丢失的初步研究[J]. 中国医科大学学报, 1997, 0(2) |
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| 作者姓名： | 王筠 张学 郝冬梅 孙开来 |
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| 作者单位： | 基础医学院医学遗传学教研室 |
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| 摘 要： | 应用ＡＰＣ基因下游４０Ｋｂ处的微卫星多态标记Ｄ５Ｓ３４６，检测３０例大肠癌组织ＤＮＡ，在可提供信息的１５例杂合子中检出５例５ｑ２１＿ｑ２２的杂合性丢失，占３３％。提示ＡＰＣ基因缺失也是中国人大肠癌的遗传改变之一
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| 关 键 词： | 大肠癌；抑癌基因；多态，遗传 |
Detection of Loss of Heterozygosity at Chromosome 5q21-q22 in Colorectal Carcinomas Using Microsatellite Marker |
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| Wang Jun,Zhang Xue,Hao Dongmei,et al. Detection of Loss of Heterozygosity at Chromosome 5q21-q22 in Colorectal Carcinomas Using Microsatellite Marker[J]. Journal of China Medical University, 1997, 0(2) |
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| Authors: | Wang Jun Zhang Xue Hao Dongmei et al |
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| Abstract: | Frequent allelic loss and mutations of the APC gene had been found in the familial and sporadic colorectal carcinomas (CA). A CA repeat polymorphic sequence in D5 S346 locus 40 Kb downstream from the APC gene, which located at chromosome 5q21-q22, was examined in 30 sporadic colorectal carcinomas. Fifteen of the 30 cases (50%) were informative, and 5 of them (33%) showed loss of heterozygosity. These results suggested that the inactivation of the APC gene was involved in the development of colorectal carcinomas in Chinese population. |
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| Keywords: | colorectal carcinomas tumor suppressor gene polymorphism genetic |
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