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Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction

Authors:	V.?Di?Lazzaro author-information" > author-information__contact u-icon-before" > mailto:vdilazzaro@rm.unicatt.it" title=" vdilazzaro@rm.unicatt.it" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,A.?Oliviero,P.?A.?Tonali,P.?Mazzone,A.?Insola,F.?Pilato,E.?Saturno,M.?Dileone,J.?C.?Rothwell

Affiliation:	(1) Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168, Rome, Italy,;(2) Neurosurgery CTO, Via S. Nemesio 21, 00145, Rome, Italy,;(3) Neurophysiology CTO, Via S. Nemesio 21, 00145, Rome, Italy,;(4) Sobell Department of Neurophysiology, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK,

Abstract:	A brief period of strong muscle contraction suppresses the amplitude of EMG responses evoked in relaxed muscle by transcranial magnetic stimulation (TMS) of the contralateral motor cortex. Here we investigate this phenomenon in more detail by recording the descending motor volleys evoked by TMS from electrodes in the cervical epidural space of three conscious patients implanted with chronic electrical stimulators for control of pain. We confirm that fatigue suppresses I waves evoked by TMS. In addition, D waves were suppressed in two of the patients, suggesting that axonal excitability might also be compromised by a period of intense muscle contraction. Electronic Publication

Keywords:	Direct demonstration Human motor cortex Fatiguing muscle contraction EMG response Transcranial magnetic stimulation Descending motor volley
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