| Brg1基因单核苷酸多态性与喉癌的相关性 |
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| 引用本文： | 王禄,宋朝霞,刘冰,孙海波,祝威. Brg1基因单核苷酸多态性与喉癌的相关性[J]. 肿瘤防治研究, 2012, 39(2): 130-132. DOI: 10.3971/j.issn.1000-8578.2012.02.003 |
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| 作者姓名： | 王禄 宋朝霞 刘冰 孙海波 祝威 |
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| 作者单位： | 1.130021长春，吉林大学基础医学院医学遗传学教研室；2.吉林大学第一医院耳鼻咽喉-头颈外科 |
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| 基金项目： | 高等学校博士学科点专项科研基金资助项目(20060183040) |
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| 摘 要： | 目的探讨Brg1基因的rs12609589和 rs73013167两个SNP位点与喉癌发生的相关性。方法选取94例喉癌患者和100例健康对照组，采用PCR-RFLP方法对两位点进行多态性分型，并对结果进行统计学分析。结果rs12609589位点C、T基因频率在病例组和对照组中无明显差异（P>0.05）；rs73013167位点G、C基因频率在病例组和对照组中有差异（P<0.05）。结论Brg1的rs12609589位点与喉癌的发生没有相关性，rs73013167可能是喉癌发生的易感位点。
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| 关 键 词： | Brg1基因 喉癌 单核苷酸 多态性 |
| 收稿时间： | 2011-05-01; |
Association between Brg1 Single Nucleotide Polymorphism and Laryngo Carcinoma |
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| Wang Lu , Song Zhaoxia , Liu Bing , Sun Haibo , Zhu Wei. Association between Brg1 Single Nucleotide Polymorphism and Laryngo Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(2): 130-132. DOI: 10.3971/j.issn.1000-8578.2012.02.003 |
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| Authors: | Wang Lu Song Zhaoxia Liu Bing Sun Haibo Zhu Wei |
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| Affiliation: | 1.Department of Medical Genetics，School of Basic Medical Sciences，Jilin University，Changchun 130021，China;2.Department of Otorhinolaryngology，The First Hospital，Jilin University |
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| Abstract: | Objective To explore the relationship between the single nucleotide polymorphism of Brg1 gene rs12609589 and rs73013167 sites and laryngo carcinoma.Methods Ninety-four sporic laryngo carcinoma patients and 100 controls were collected and DNA was isolated from blood samples.The single nucleotide polymorphism of Brg1 was analyzed using PCR-RFLP.Results No remarkable difference of C and T allele frequencies between case and control groups was observed in rs12609589(P>0.05).In rs73013167,however,the G and C allele frequencies was remarkable difference between case and control groups(P<0.05).Conclusion Brg1 rs73013167 was related to laryngo carcinoma although rs12609589 was not. |
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| Keywords: | Brg1 Laryngo-carcinoma Single nucleotide Polymorphism |
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