TACE治疗肝癌的不良反应临床观察

目的探讨TACE治疗肝癌的不良反应情况,为其临床防治提供依据。方法通过回顾性分析81例(Child-pugh A级)肝癌切除术后复发患者TACE术后出现的不良反应情况,与同期同级的267例初诊中晚期肝癌患者进行对比。结果复发组ALT、AST在TACE术后1周恢复至术前水平,而STB、DBIL、STP、A、ChE在术后2周恢复至术前水平,无严重不良反应;中晚期组肝功能均需要2周才能恢复至术前水平。结论 Child-pugh A级肝癌在TACE术后肝功能损害为可逆性;TACE对肝脏合成功能及储备功能损伤持续时间长,恢复较慢。

Clinical observation on adverse effects of transcatheter arterial chemoembolization in treatment of hepatic carcinoma

Objective To evaluate the adverse effects of transcatheter arterial chemoembolization(TACE) for hepatic carcinoma to provide the basis for its clinical prevention and treatment.Methods Adverse effects of 81 cases with postoperative recurrence of hepatic carcinoma(in Child-pugh A grade) undergoing TACE were retrospectively analyzed,with 267 cases of newly diagnosed as primary hepatic carcinoma in advanced stage undergoing of TACE in the same period for comparison.Results ALT and AST of recurrence group returned to previous levels in one week after TACE,while STB and DBIL,STP,A,and ChE in two weeks.No severe adverse effect was observed.However,the changse of liver function indicators in advanced group all returned to previous levels in two weeks after TACE.Conclusions In Child-pugh A grade of hepatic carcinoma,the damage of liver function is reversible after TACE.However,the damage of liver synthetic function and reserve function last for a longer period of time,and the recovery rate are slower.