| 抗原NY-BR-1的HLA-A2限制性CTL表位的初步鉴定 |
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| 引用本文： | 赵婷婷,吴玉章,林治华,周伟,贾正才,邹丽云.抗原NY-BR-1的HLA-A2限制性CTL表位的初步鉴定[J].中国免疫学杂志,2003,19(8):540-543. |
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| 作者姓名： | 赵婷婷 吴玉章 林治华 周伟 贾正才 邹丽云 |
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| 作者单位： | 第三军医大学全军免疫研究所,重庆,400038 |
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| 基金项目： | 本研究为国家自然科学基金资助项目(批准号:30200277) |
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| 摘 要： | 目的：鉴定乳腺癌分化肿瘤抗原NY-BR-1的HLA-A2限制性CTL表位。方法：采用量化基序法初步预测NYBR-1的HLA-A2限制性CTL表位；分子动力学方法进一步筛选量化基序法中评分最高的3个表位肽；HLA-A2亲合力鉴定预测的结果。结果：分子动力学和HLA-A2亲合力实验均证明，在量化基序法预测的3个候选CTL表位中，NY-BR-11043-1051与HLA-A2亲合力最佳。结论：NY-BR-11043-1051可能为乳腺癌分化抗原NY-BR-1的HLA-A2限制性CTL表位。
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| 关 键 词： | 抗原NY-BR-1 HLA-A2限制性 CTL表位 鉴定 乳腺癌 |
| 文章编号： | 1000-484X(2003)08-0540-04 |
Identification a HLA-A2-restricted CTL epitope of breast cancer differentiation antigen NY-BR-1 |
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| ZHAO Ting-Ting,WU Yu-Zhang,LIN Zhi-Hua et al.Identification a HLA-A2-restricted CTL epitope of breast cancer differentiation antigen NY-BR-1[J].Chinese Journal of Immunology,2003,19(8):540-543. |
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| Authors: | ZHAO Ting-Ting WU Yu-Zhang LIN Zhi-Hua |
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| Institution: | ZHAO Ting-Ting,WU Yu-Zhang,LIN Zhi-Hua et al.Institute of Immunology PLA,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Objective:To identify HLA-A2-restricted CTL epitope of breast cancer differentiation antigen NY-BR-1.Methods:The HLA-A2-restricted CTL epitope of breast cancer differentiation antigen NY-BR-1 is predicted by combination quantitative motif method and the molecular dynamics.The three epitope were assayed their affinity to HLA-A2.Results:The affinity to HLA-A2 of NY-BR-1_ 1043-1051 is a best.Conclusion:NY-BR-1_ 1043-1051 is a HLA-A2 restricted epitope. |
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| Keywords: | Breast cancer NY-BR-1 CTL epitope Prediction Identification |
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