Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus |
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| Authors: | Alessandro Stefani Salvatore Galati Antonella Peppe Andrea Bassi Mariangela Pierantozzi Atticus H Hainsworth Giorgio Bernardi Antonio Orlacchio Paolo Stanzione Paolo Mazzone |
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| Institution: | (1) CERC-IRCCS Fondazione S. Lucia, Via Ardeatina 306, Roma, Italy;(2) Dipartimento Neuroscienze, Clinica Neurologica, Università di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy;(3) Pharmacology Group, School of Pharmacy, De Montfort University, Leicester, United Kingdom;(4) Divisione di Neurochirurgia, Unità di Neurochirurgia Stereotassica e Funzionale, Ospedale CTO, ASL RMC, Roma, Italy |
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| Abstract: | In Parkinson’s disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations
have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting
micro-recordings of STN single units in Parkinson’s disease (PD) patients, here we show that the neurons that are responsive
to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized
by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input
modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features
are potential targets for future therapeutic interventions. |
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| Keywords: | DBS Basal ganglia Firing pattern Parkinson’ s disease Vigilance |
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