| 水红花子对免疫性肝损伤小鼠肝功能的影响 |
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| 引用本文： | 杜宇琼,赵晖,高连印,黄静娟,刘树军.水红花子对免疫性肝损伤小鼠肝功能的影响[J].辽宁中医杂志,2007,34(1):116-117. |
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| 作者姓名： | 杜宇琼 赵晖 高连印 黄静娟 刘树军 |
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| 作者单位： | 首都医科大学中医药学院,北京,100069 |
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| 摘 要： | 目的:观察人用口服剂量40倍的水红花子20g/(kg.d)对免疫性肝损伤小鼠的影响。方法:观察水红花子20g/(kg.d)对BCG/LPS致免疫性肝损伤模型小鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性,肝组织超氧化物歧化酶(SOD)、丙二醛(MDA)含量的影响。结果:水红花子20g/(kg.d)肝脏病理损伤明显,血清ALT、AST均显著升高(P<0.01),肝组织SOD值明显下降(P<0.05),MDA明显升高(P<0.05)。结论:人用口服剂量40倍的水红花子20g/(kg.d)可提高免疫性肝损伤小鼠的肝脏损伤程度,具有肝毒性。其肝损伤的作用环节可能与诱导肝脏自由基的生成,降低自由基清除酶的功能,破坏自由基代谢的动态平衡有关。
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| 关 键 词： | 水红花子 免疫性肝损伤 实验研究 |
| 文章编号： | 1000-1719(2007)01-0116-02 |
| 修稿时间： | 04 17 2006 12:00AM |
Experimental Study on the Effects of Fructus Polygoni Orentalis on BCG/LPS -induced Mice Liver Injury |
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| DU Yu-qiong,ZHAO Hui,GAO Lian-yin,HUANG Jing-juan,LIU Shu-jun.Experimental Study on the Effects of Fructus Polygoni Orentalis on BCG/LPS -induced Mice Liver Injury[J].Liaoning Journal of Traditional Chinese Medicine,2007,34(1):116-117. |
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| Authors: | DU Yu-qiong ZHAO Hui GAO Lian-yin HUANG Jing-juan LIU Shu-jun |
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| Institution: | TCM College of Capital Medical University,Beijing 100069, China |
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| Abstract: | Objective:To explore the effect of Fructus Polygoni Orentalis on immune liver injury in mice induced by BCG/LPS.Methods:Fructus Polygoni Orentalis was given to the mice model of immune liver injury.The samples of liver and blood were measured.The damage of liver tissues was observed by light microscope.Results:Compared with the model group,the Fructus Polygoni Orentalis could obviously increase the serum ALT and AST activity and decrease the SOD activity.Conclusion:Liver damage was exacerbated at Fructus Polygoni Orentalis treated group at 20g/(kg·d) dose.The mechanism may be associated with its ability of decreasing the activity of clearance enzyme of free radical. |
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| Keywords: | fructus pelygoni orentalis immune liver injury experimental study |
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