| 硒、锌对氟致大鼠大脑神经细胞DNA损伤的影响 |
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| 引用本文： | 陈军,陈学敏,杨克敌. 硒、锌对氟致大鼠大脑神经细胞DNA损伤的影响[J]. 卫生研究, 2000, 29(4): 216-217 |
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| 作者姓名： | 陈军 陈学敏 杨克敌 |
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| 作者单位： | 同济医科大学环境卫生教研室,武汉,430030 |
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| 基金项目： | “九·五”国家医学科技攻关!项目 (No.96 -90 6 -0 4-0 2 |
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| 摘 要： | 为研究氟对大鼠大脑皮层神经细胞的ＤＮＡ损伤作用及硒、锌单独及联合作用对其的影响，对大鼠体外染毒后采用单细胞凝胶电泳技术检测ＤＮＡ单链断裂。结果显示单独加氟、硒组ＤＮＡ损伤程度显著大于对照组（Ｐ〈０．０１），且氟的影响更为严重，氟硒组和氟锌组ＤＮＡ损伤程度小于氟组，但差异无显著性意义，氟硒锌组ＤＮＡ损伤程度显著低于氟组（Ｐ〈０．０５）。提示氟、硒单独作用均造成大脑皮层神经细胞ＤＮＡ损伤，硒锌联合中明
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| 关 键 词： | 氟 硒 锌 DNA损伤 大脑皮层神经细胞 |
Effects of selenium and zinc on the DNA damage caused by fluoride in pallium neural cells of rats |
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| Chen Jun,Chen Xuemin,Yang Kedi. Effects of selenium and zinc on the DNA damage caused by fluoride in pallium neural cells of rats[J]. Journal of hygiene research, 2000, 29(4): 216-217 |
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| Authors: | Chen Jun Chen Xuemin Yang Kedi |
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| Affiliation: | Department of Environmental Health, Tongji Medical University, Wuhan 430030, China. |
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| Abstract: | To investigate the effects of fluoride on DNA damage as well as the effects of selenium and zinc against fluoride respectively or jointly in pallium neural cells of rats ,single cell gel electrophoresis was used to detectthe DNA dam age of neural cells prepared in vitro.The results showed that the degree of DNA dam age in the fluoride group and the selenium group were significantly greater than that in control group(P <0 .0 1) .The damage in the fluoride group was even more serious.The damage in the fluoride selenium group and fluoride zinc group was slighter than that in the fluoride group but with no significant difference.The extent of DNA dam age in the fluoride selenium zinc group was significantly slighter than that in the fluoride group(P<0 .0 5 ) .It suggested that fluoride and selenium could induce DNA damage in pallium neural cells of rats respectively.Moreover,the joint antagonistic effect of selenium and zinc against fluoride was more obvious. |
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| Keywords: | fluoride selenium zinc DNA damage pallium neural cell |
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