| 甲磺酸伊马替尼的不良反应及预防处理 |
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| 引用本文： | 吴洪斌,陆益,陆国椿.甲磺酸伊马替尼的不良反应及预防处理[J].中国新药杂志,2006,15(22):1923-1925,1929. |
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| 作者姓名： | 吴洪斌 陆益 陆国椿 |
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| 作者单位： | 复旦大学附属肿瘤医院药剂科,上海,200032 |
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| 摘 要： | 甲磺酸伊马替尼（imafinib mesylate，Glivec，格列卫）是一种口服的新型酪氨酸激酶抑制剂，被FDA批准用于治疗慢性粒细胞白血病（CML）及恶性转移性或手术无法切除的胃肠道间质瘤（GIST），疗效显著。其不良反应包括血液学毒性和非血液学毒性，血液学毒性主要表现为自细胞、血红蛋白和血小板减少；非血液学毒性表现为水肿和水钠潴留、肌痛及肌痉挛、恶心、呕吐、腹泻等。现概述甲磺酸伊马替尼不良反应类型及临床上采取的预防措施和常规处理方法。
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| 关 键 词： | 甲磺酸伊马替尼 药物不良反应 血液学毒性 水肿 肌痛及肌痉挛 腹泻 恶心 呕吐 |
| 文章编号： | 1003-3734（2006）22-1923-04 |
| 收稿时间： | 2006-03-10 |
| 修稿时间： | 2006-03-10 |
Adverse effects and precautions of imatinib mesylate |
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| WU Hong-bin,LU Yi,LU Guo-chun.Adverse effects and precautions of imatinib mesylate[J].Chinese Journal of New Drugs,2006,15(22):1923-1925,1929. |
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| Authors: | WU Hong-bin LU Yi LU Guo-chun |
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| Institution: | Department of Pharmacy, Cancer Hospital of Fudan University, Shanghai 200032, China |
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| Abstract: | Imatinib mesylate (Glivec)is a selective EGFR-TK (epidermal growth factor receptor tyrosine kinase) inhibitor.It shows antitumour activity in the treatment of chronic myeloid Ieukemia (CML) and unresectable and/or metastatic gastrointestinal stromal tumors (GIST),approved by FDA in May 2001 and February 2002.The main adverse effects of imatinib mesylate are haematological and non- haematological toxicities.The haematologieal toxicities included leucopenia,anemia,thrombocytopenia. The nonhaematological toxicities included edema (mainly periorbital edema),myalgia and muscle cramps,nausea,vomiting,diarrhea.The side effects and precautions of imatinib mesylate were reviewed in this paper. |
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| Keywords: | imatinib mesylate adverse effects haematological toxicity edema myalgia and mus- cle cramps diarrhea nausea vomiting |
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