| 益气活血汤抑制实验兔PDGF表达和血管平滑肌细胞表型转变的研究 |
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| 引用本文： | 林萍,杨关林,周鑫.益气活血汤抑制实验兔PDGF表达和血管平滑肌细胞表型转变的研究[J].辽宁中医药大学学报,2009(7). |
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| 作者姓名： | 林萍 杨关林 周鑫 |
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| 作者单位： | 辽宁中医药大学附属医院; |
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| 摘 要： | 目的:观察益气活血汤对高脂饲料喂养的实验兔机械损伤后血管平滑肌细胞(VSMC)表型转变和血小板衍生生长因子-B(PDGF-B)表达的研究。方法:将32只健康新西兰大耳白兔随机分为4组:正常对照组(A)、模型组(B)、西药组(C)和中药组(D),分别给予普通饲料、高脂饲料、高脂饲料加来适可胶囊和高脂饲料加益气活血汤灌胃喂饲。实验第5周,B、C、D组均行右侧腹-髂动脉内膜球囊损伤术。7周末采取球囊损伤血管以及正常组相对应部位血管在透射电镜下进行病理形态学观察并用逆转录-聚合酶链反应方法观察PDGF-B的表达。结果:PDGF-B模型组表达量高于中药组及西药组(P<0.05)。模型组家兔血管平滑肌细胞表型由收缩型转变为合成型。结论:动脉损伤后PDGF表达增加,益气活血汤组家兔PDGF表达与模型组比较明显减少,提示益气活血汤对PDGF表达一定抑制作用。模型组血管平滑肌细胞由收缩型转变为合成型,而益气活血汤组家兔表型转变不明显,提示益气活血汤可能通过影响PDGF表达影响平滑肌细胞表型转变。
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| 关 键 词： | 益气活血汤 血管平滑肌细胞 表型 PDGF-B |
Effect of YQHXT on PDGF Gene Expression and Changed Phenotype in Smooth Muscle Cell in Atherosclerotic Rabbit |
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| LIN Ping,YANG Guan-lin,ZHOU Xin.Effect of YQHXT on PDGF Gene Expression and Changed Phenotype in Smooth Muscle Cell in Atherosclerotic Rabbit[J].Journal of Liaoning University of Traditional Chinese Medicine,2009(7). |
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| Authors: | LIN Ping YANG Guan-lin ZHOU Xin |
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| Institution: | Affiliated Hospital Affiliated to Liaoning University of TCM;Shenyang 110032;Liaoning;China |
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| Abstract: | Objective: Effect of Yiqihuoxue decoction (YQHXT) on PDGF Gene Expression and Changed Phenotype in Smooth Muscle Cell in Atherosclerotic Rabbit.Method: 32 healthy rabbits were randomly divided into four groups: Normal control group(A), Model group(B), Fluvastatin group(C) and YQHXT group(D).The four groups were given ordinary feed, high fat diet, high fat diet with Fluvastatin capsules, highfat diet with YQHXT.After 5 weeks,group B,C and D were given Right abdomen - iliac artery balloon injury of endometria... |
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| Keywords: | Yiqihuoxue decoction Vascular Smooth Muscle Cell Phenotype PDGF-B |
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