Comparison of taurine, hypotaurine and β-alanine uptake in brain synaptosomal preparations from developing and adult mouse

The properties of taurine, hypotaurine and β-alanine uptakes were compared in brain synaptosomal preparations from 6-day-old and adult mice. The uptakes of these structurally related amino acids resembled each other, being concentrative, sodium-dependent and inhibited by the same analogues. The absolute sodium requirement of uptake was already evident in developing brain. The affinity of the lowaffinity uptake for taurine was higher in immature than in adult brain. Both affinity and maximal velocity increased in hypotaurine uptake during development, whereas in β-alanine uptake only the maximal velocity did so. The efficient synaptosomal taurine and hypotaurine transport systems in immature brain could contribute to the high taurine level in developing brain.