高白细胞性急性白血病50例临床研究

目的探讨高白细胞性急性白血病（HAL）的临床特征、治疗效果及预后分析。方法对50例HAL进行临床回顾性分析，同时以100例非高白细胞性急性白血病（NHAL）作对照纽。结果HAL症状重；HAL治疗有效率为58．0％，低于NHAL的76．0％；HAL组早期病死率是22．0％，高于对照组的9．0％，有统计学差异。结论HAL治疗有效率低，早期病死率高，预后差，应化疗前行白细胞单采术有效降低白细胞数，再给予足量、规范的联合化疗，预防各种并发症，才能有效地提高临床疗效，降低病死率。

Clincal study on SO patients witlI hyperleukocytic acute leukemia

Objective To investigate the clinical Characteristi - cs, therapeutic effects and the prognostic factors of patients with hyperleukocytic acute leukemia （ HAL）. Methods Reviewed 50 patients with acute leukemia characterized with hyperleukoeyto - sis and 100 cases of nonhyperleukocytic acute leukemia（NHAL）. Results The symptom of HAL was heavier than NHAL. After treatment, the effective ratio of HAL,which was 58.0% , was lower than that of NHAL,which was 76.0% . The early mortality rate of HAL, which was 22.0% , was higher than that of NHAL, which was 9.0%. There was significant difference （ P 〈 0.05 ）. Conclusion HAL patients have poor prognosis, low effective ratio of threatment and high early mortality rate.