(+)-[3H]SK&F 10,047 binding sites in rat liver |
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| Authors: | N N Samovilova L V Nagornaya V A Vinogradov |
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| Affiliation: | Laboratory of Peptide Biochemistry and Pharmacology, Institute of Experimental Cardiology, Cardiology Research Center of the USSR, Moscow. |
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| Abstract: | Stereospecific binding sites for (+)-[3H]SKF 10,047 have been demonstrated in rat liver. These binding sites were shown to be opioid receptors of the sigma type, and this was confirmed by their binding properties: reversibility, saturability, stereospecificity, effects of ions and various pharmacological drugs on (+)-[3H]SK sigma F 10,047 binding. The authors suggest that (+)-[3H]SKF 10,047 binding sites in liver and brain are a part of novel 'sigmergic' regulatory system. |
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