| 乳腺癌中癌基因抗癌基因表达分析 |
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| 引用本文： | 牛瑞芳,杨毅,刘红,史玉荣,魏熙胤,孙保存,郝希山. 乳腺癌中癌基因抗癌基因表达分析[J]. 中国肿瘤临床, 2003, 30(3): 167-171 |
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| 作者姓名： | 牛瑞芳 杨毅 刘红 史玉荣 魏熙胤 孙保存 郝希山 |
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| 作者单位： | 天津市肿瘤医院,肿瘤研究所基因芯片研究中心,天津市,300060 |
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| 基金项目： | 天津市科委重大攻关项目基金资助(编号:013182311) |
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| 摘 要： | 目的：分析乳腺癌中癌基因。抗癌基因的表达，探讨乳腺癌的发病机制。方法：分别用Cy3和Cy5标记正常乳腺组织和乳腺癌组织的mRNA，与癌基因抗癌基因分类芯片进行杂交。分析两组表达差异。结果：差异表达的基因有39条。其中下调表达的基因有8条。上调表达的基因有31条。结论：说明乳腺癌的发生主要与大量癌基因的过量表达相关。
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| 关 键 词： | 乳腺癌 癌基因 抗癌基因 基因芯片 |
| 文章编号： | 1000-8179(2003)03-0167-05 |
| 修稿时间： | 2002-05-22 |
Analysis of the Expression of Oncogene and Antioncogene in Breast Cancer |
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| Niu Ruifang Yang Yi Liu Hong et al Gene Chip Research Center,Tianjin Cancer Hospital and Institute,Tianjin. Analysis of the Expression of Oncogene and Antioncogene in Breast Cancer[J]. Chinese Journal of Clinical Oncology, 2003, 30(3): 167-171 |
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| Authors: | Niu Ruifang Yang Yi Liu Hong et al Gene Chip Research Center Tianjin Cancer Hospital Institute Tianjin |
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| Abstract: | Objective:Analysis the expression of oncogene and antioncogene in breast can-cer and try to find the pathogenesis of breast cancer.Methods:The mRNA of normal breast tis-sue and breast cancer tissue were labelled by Cy3and Cy5,and hybridized with the classified gene chip of oncogene and antioncogene.Results:There were39genes of differential expression.Among these genes there were8genes of decrease expression and31genes of increase expres-sion.Conclusion:The pathogenesis of breast cancer mainly concerned with the overdos expres-sion of a lot of oncogenes. |
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| Keywords: | Breast cancer Oncogene Antioncogene Gene chip |
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