Protective effect of retinoic acid on interleukin-1 beta-induced cytotoxicity of pancreatic beta-cells |
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| Authors: | Kang Mi-Kyung Yoon Yeo-Eun Yang Jeong-Yeh Kwon Kang-Beom Park Jin-Woo Jhee Eun-Chung |
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| Institution: | Department of Oral Biochemistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju 561-756, South Korea. |
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| Abstract: | Cytokines produced by immune cells in pancreatic islets infiltrating are important mediators of beta-cell destruction in insulin-dependent diabetes mellitus. In this study, the effects of retinoic acid (RA) on cytokine-induced beta-cell dysfunction were examined. RA significantly protected interleukin-1 beta (IL-1) and interferon-gamma (IFN-gamma)-mediated cytotoxicity of rat insulinoma cell (RINm5F), and also reduced in IL-1 and IFN-gamma-induced nitric oxide (NO) production, which correlated well with reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein. The molecular mechanism, by which RA inhibited iNOS gene expression, appeared to involve the inhibition of NF-kappa B activation. Our results suggest possible therapeutic value of RA for the prevention of diabetes mellitus progression. |
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| Keywords: | Nitric oxide Retinoic acid Inducible nitric oxide synthase NF-κB activation |
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