血管内皮生长因子在早期异位妊娠及宫内胚胎停育的表达

[目的]通过检测血清血管内皮生长因子(VEGF)、绒毛膜促性腺激素(HCG)在宫内早孕(IUP)、宫内胚胎停育(aIUP)及异位妊娠(EP)中的不同浓度,探讨VEGF在停经早期鉴别EP及aIUP的意义。[方法]选择孕40d左右妇女,采用酶联免疫聚合反应(ELISA)检测20例正常IUP妇女(正常对照组)、15例aIUP(自然流产组)及20例EP妇女血清VEGF和HCG的浓度,并进行对比分析。[结果]血清VEGF浓度EP组为(295.6±52.1)pg/m l,明显高于IUP组的(40.4±21.5)pg/m l和aIUP组的(110.3±34.5)pg/m l,差异均有显著性(P<0.01,P<0.05);HCG在EP组为(2092.8±1634.1)m Iu/m l、aIUP组为(2352.4±1712.8)m Iu/m l,都明显低于IUP组的(14780.6±8777.3)m Iu/m l,差异均有显著性(P<0.01),而EP组与aIUP相比差异无显著性(P>0.05)。[结论]VEGF在EP的高表达将有助于EP的早期诊断,VEGF可用于鉴别早期EP与aIUP,与HCG相比具有优越性。

The expression of serum vascular endothelial growth factor in ectopic and arrested intrauterine pregnancies

[Objective] To evaluate serum vascular endothelial growth factor(VEGF) and HCG levels in women with normal intrauterine pregnancy(IUP),arrested IUP(aIUP) and ectopic pregnancies(EP) at early gestation. [Methods] A prospective case-control study was conducted comparing serum VEGF and HCG concentrations among 50 women with early pregnancies who subsequently had 20 normal IUP,15 arrested IUP and 20 EP. [Results] There was a significant difference in VEGF concentrations among women with EP,arrested IUP and normal IUP.VEGF showed statistically significant differences between EP and the other 2 groups (P<0.05);HCG showed statistically significant differences between normal IUP and the other 2 groups(P<0.01),but not between EP and arrested IUP (P>0.05). [Conclusion] VEGF can discriminate EP from arrested IUP at early pregnancies while HCG cannot.VEGF is a potential marker for early diagnosis of EP.