咯萘啶-蒿甲醚-氯喹联合治疗食蟹猴疟原虫感染恒河猴的研究

咯萘啶6 mg base/kg、蒿甲醚100 mg/kg、氯喹10 mg base/kg联合给药,1次/d×31个疗程,对恒河猴的血传感染,可完全清除血内原虫的无性体;对恒河猴的子孢子感染,与单用氯喹比较,可见原虫再现(包括复燃和复发,下同)次数明显减少。食蟹猴疟原虫没有出现远期复发。三种药物联合3 d治疗对猴有较严重的胃肠道副作用。

A COMBINED REGIMEN OF PYRONARIDIN-ARTEMETHERCHLOROQUINE (PAC) FOR THE TREATMENT OF PLASMODIUM CYNOMOLGI IN RHESUS MONKEY

A combined regimen of PAC was studied in rhesus monkey infected with Plasmodium cynomolgi. Monkeys infected by blood transmission were rapidly cured after combined treatment with PAC once daily for 3 days. In the observation period asexual parasites reappeared only once or twice, wich might be short-term relapses, in animals infected by sporozoites. On the other hand, much more frequent parasite reappearance occurred in animals treated with chloroquine alone or PAC in one day course.According to the assumption of "hypnozoite" in sporozoite-induced infection, long-term relapses would be expected after the primary onset and a period of negative parasitemia. However, it was not confirmed in this study, as no long-term relapse was detected in animals followed for more than 300 days.Side effects occurred mainly in the gastro-intestinal tract of monkeys receiving a 3-day course of PAC.