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Mutational specificity of the syn 1,2-dihydrodiol 3,4-epoxide of 5-methylchrysene |
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| Authors: | John E. Page John Pataki Ronald G. Harvey Anthony Dipple |
| Affiliation: | a Chemistry of Carcinogenesis Laboratory, ABL-Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA b Ben May Institute, University of Chicago, Chicago, IL 60637, USA |
| Abstract: | The mutational specificity of the syn dihydrodiol epoxide of 5-methylchrysene in the supF gene of the pSP189 vector was examined. Transversion mutations at GC pairs predominated with G → T and G → C changes accounting for 42 and 21% of total base change mutations. The types of mutations found reflect the previously determined chemical preference of this reactive species for reaction with deoxyguanosine residues in DNA. |
| Keywords: | Mutational spectra Dihydrodiol epoxide 5-Methylchrysene |
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