VEGF-C在直肠癌中的表达与临床病理特征的关系

目的 研究VEGF-C在直肠癌中的表达情况及其与临床病理特征之间的关系.方法 对2007年12月至2008年8月行直肠癌手术治疗的82例中低位直肠癌患者的肿瘤组织标本和各站淋巴结,用免疫组化方法检测VEGF-C在直肠癌组织中以及CK20在直肠癌D3站淋巴结中表达的情况,结合系膜淋巴结的病理结果,阐述VEGF-C在直肠癌组织中的表达与临床病理特征之间的关系.统计方法采用X~2检验.结果直肠癌中VEGF-C的表达在肿瘤分期各组中差异有统计学意义(X~2=8.529,P<0.05),在无淋巴结转移组和系膜0淋巴结转移组中差异有统计学意义(X~2=4.712,P<0.05),在患者性别与年龄对比中差异无统计学意义(X~2=0.227,P>0.05;X~2=0.037,P>0.05),无淋巴结转移组与系膜淋巴结转移组的VEGF-C表达差异有统计学意义(X~2=4.712,P<0.05),而系膜淋巴结转移组与D3淋巴结转移组的表达差异无统计学意义(X~2=0.017,P>0.05).结论 VEGF-C的表达与肿瘤分期及淋巴结转移有关,但与患者的性别和年龄无关;VEGF-C的表达在促进直肠癌发生区域淋巴结转移的同时,也可能促进D3淋巴结微转移.

Expression of VEGF-C and it's relationship with clinical pathologic characteristics in rectal cancer

Objective To study the expression of VEGF-C and it's relationship with pathologic characteristics in rectal cancer.Method In this study 82 patients of mid to low rectal cancer underwent radieal resection from December 2007 to August 2008.Tumor tissues and lymph nodes were studied by immunohistochemical staining for VEGF-C expression in the tumor tissue and CK20 expression in D3 lymph nodes.Results were compared with the pathological results of mesenterium lymph nodes to explain the relationships between VEGF-C expressions and clinical pathologic characteristics.Data were analyzed with Chi square test.Result As for the expression of VEGF-C.significant differences were found between tumor stages(X~2=8.529,P<0.05)and between positive and negative lymph node metastasis(X~2=4.712,P<0.05).but there was no difference between that of mesenterium lymph node metastasis and D3 lymph node micrometastasis(X~2=0.017,P>0.05). Conclmion In rectal cancer,VEGF-C expression is correlated with tumor stage,type,metastasis and micrometastasis of lymph node.