| 氧氟沙星与左氧氟沙星不良反应个案调查与分析 |
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| 引用本文： | 田强,权菊香,赵桂元. 氧氟沙星与左氧氟沙星不良反应个案调查与分析[J]. 中国临床药理学杂志, 2012, 0(8): 614-617 |
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| 作者姓名： | 田强 权菊香 赵桂元 |
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| 作者单位： | 华北石油管理局总医院心胸外科;北京大学第一医院临床药理研究所 |
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| 摘 要： | 目的分析氧氟沙星与左氧氟沙星近10年药物不良反应(ADR)的异同。方法从CNKI数据库和维普数据库中检索两药不良反应的个案报道,用Epi-data软件收集患者性别、年龄、用药原因、给药途径、给药剂量、不良反应发生时间及表现等并进行分析。结果本次调查共收集不良反应报道氧氟沙星48篇(54例),左氧氟沙星133篇(175例),用药病因均以呼吸系统感染为主(46.3%vs 41.7%)。2种药物相同ADR为癫痫大发作、抽搐、谵妄、震颤、过敏性休克等。结论氧氟沙星与左氧氟沙星的不良反应不尽相同。
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| 关 键 词： | 氧氟沙星 左氧氟沙星 药物不良反应 |
Investigation and analysis the adverse drug reaction of ofloxacin and levofloxacin |
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| TIAN Qiang,QUAN Ju-xiang, ZHAO Gui-yuan. Investigation and analysis the adverse drug reaction of ofloxacin and levofloxacin[J]. The Chinese Journal of Clinical Pharmacology, 2012, 0(8): 614-617 |
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| Authors: | TIAN Qiang QUAN Ju-xiang ZHAO Gui-yuan |
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| Affiliation: | 1.Department of Cardiothoracic Surgery,North China Peroleum Menagement Bureau General Hospital,Cangzhou,062552,Hebei Province,China;2.Institute of Clinical Charmacology,Peking University First Hospital,Beijing 100034,China) |
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| Abstract: | Objective To analyse the difference of ofloxacin and levofloxacin on the adverse drug reaction(ADR).Methods Searches the case reported of ADR reaction of ofloxacin and levofloxacin from CNKI database and VIP database.Collecting the patients’ gender,age,disease,reasons,route of administration,daily dose,time and performance with Epidata and analyzing.Results There are 48 reports(54 patients) of ofloxacin and 133 reports(175 patients) of levofloxacin.The both of main medicine etiology are respiratory tract infection(46.3% vs 41.7%).There were similar symptoms of ofloxacin and levofloxacin on the ADR such as grand mal epilepsy,convulsions,delirium,tremor and allergic shock,etc.Conclusion Ofloxacin and levofloxacin adverse reactions have many similar and also there are many differente. |
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| Keywords: | ofloxacin levofloxacin adverse drug reaction |
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