Analysis of the Relationship between Expressions of TF and MMP-9 and Prognosis of Breast Cancer Patients |
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作者单位: | Jianxin Zhao Zengmao Lin Hongwei Yao Yuanlian Wan Department of General Surgery,No.1 Hospital of Beijing University,Beijing 100034,China. |
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摘 要: | OBJECTIVE To investigate expression of the tissue factor (TF)and matrix metalloproteinase-9(MMP-9)in breast cancers, and to assess their expression in relation to possible prognostic significance. METHODS The expression of TF and MMP-9 in 71 breast cancer specimens were determined by EnVision immunohistochemistry, and the positive expressions related to the patient clinical outcome. RESULTS Positive rates of TF and MMP-9 staining were respectively 43.7%and 42.3%.K-M monofactorial analysis showed that the 5-year survival rate of the patients with a positive expression of TF and MMP-9 was lower than those with negative expression(P<0.05).However,the COX multifactorial analysis indicated that TNM staging and lymph node metastasis were the prognostic factors for breast cancer patients,and that TF and MMP-9 could not be used as the independent prognostic factors(P >0.05). CONCLUSION The positive rates of TF and MMP-9 were considerably high in breast cancers,which could provide useful information for patient prognosis.
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关 键 词: | MMP-9 TF 免疫组织化学 乳腺癌 治疗方法 |
收稿时间: | 3 December 2009 |
Analysis of the relationship between expressions of TF and MMP-9 and prognosis of breast cancer patients |
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Authors: | Jianxin Zhao Zengmao Lin Hongwei Yao Yuanlian Wan |
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Institution: | Department of General Surgery, No.1 Hospital of Beijing University, Beijing 100034, China |
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Abstract: | OBJECTIVE To investigate expression of the tissue factor(TF) and matrix metalloproteinase-9 (MMP-9) in breast cancers,and to assess their expression in relation to possible prognostic significance.METHODS The expression of TF and MMP-9 in 71 breast cancer specimens were determined by EnVision immunohistochemistry,and the positive expressions related to the patient clinical outcome.RESULTS Positive rates of TF and MMP-9 staining were respectively 43.7% and 42.3%. K-M monofactorial analysis showed that the 5-year survival rate of the patients with a positive expression of TF and MMP-9 was lower than those with negative expression (P < 0.05). However, the COX multifactorial analysis indicated that TNM staging and lymph node metastasis were the prognostic factors for breast cancer patients, and that TF and MMP-9 could not be used as the independent prognostic factors (P> 0.05).CONCLUSION The positive rates of TF and MMP-9 were considerably high in breast cancers, which could provide useful information for patient prognosis. |
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Keywords: | breast cancer MMP-9 TF immunohistochemistry prognosis |
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