食管癌分子生物学研究进展

分子生物学研究显示食管癌的发生发展过程中有许多基因及蛋白发生改变.与食管癌癌前病变相关的分子事件主要有p53基因突变及蛋白的过表达、一些基因位点的杂合性丢失及DNA甲基化及一些染色体非整倍体的出现;与食管癌治疗及预后密切相关的生物标志物主要有P53蛋白、表皮生长因子受体(EGFR)、趋化因子受体-4(CXCR-4)等.

Molecular biology of esophageal cancer

Molecular biology studies show that many proteins and genes are involved in the tumorigen-esis of esophageal carcinoma. The molecular events, including p53 gene mutation and over-expression, loss of heterozygosity, DNA methylation, aneuploid, are correlated with precancerous lesions of esophageal cancer. Some biomarkers such as P53 protein, epidermal growth factor receptor, CXCR-4 are correlated closely with the therapeutic reaction and prognosis of esophageal cancer.