| C型凝集素受体Dectin-2的生物学特性及功能 |
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| 引用本文： | 陈妍洁,汪澜,刘瑞梓.C型凝集素受体Dectin-2的生物学特性及功能[J].国际免疫学杂志,2010,33(2):110-113. |
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| 作者姓名： | 陈妍洁 汪澜 刘瑞梓 |
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| 作者单位： | 复旦大学上海医学院,上海,200032 |
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| 基金项目： | 国家基础科学人才培养基金 |
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| 摘 要： | 树突细胞相关凝集素2（Dectin-2）是一种新发现的C型凝集素受体，具有一个碳水化合物识别域CRD，可识别高甘露糖结构，广泛存在于树突状细胞等固有免疫细胞表面。由于其具有抗真菌病原体感染和紫外线诱导耐受等作用，因此在机体的免疫系统中发挥重要作用。对于Dectin-2等C型凝集素受体的深入研究将有利于我们对微生物感染、肿瘤免疫和自身免疫等方面有更深入的认识，从而对预防和治疗疾病起着指导作用。
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| 关 键 词： | C型凝集素受体 Dectin-2 |
The biological characteristic and function of Dectin-2,a new C-type lectin receptor |
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| CHEN Yan-jie,WANG Lan,LIU Rui-zi.The biological characteristic and function of Dectin-2,a new C-type lectin receptor[J].International Journal of Immunology,2010,33(2):110-113. |
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| Authors: | CHEN Yan-jie WANG Lan LIU Rui-zi |
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| Institution: | . (Shanghai Medical College Fudan University, Shanghai 200032, China) |
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| Abstract: | Dectin-2 is a dendritic cell-related C-type with one carbohydrate-recognition domain(CRD).which can recognise the high-mannose structure.It plays an important role in the innate immune system because of its antifungus capasity and its role in UV-induced tolerance.Further study on Dectin-2 and other C-type lectin receptors will allow us to have a deep understanding in the prevention and treatment of microbial infection.tumor immunity and autoimmunity. |
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| Keywords: | Dectin-2 |
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