| 脂联素抵抗研究进展 |
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| 引用本文： | 林家煜,施亚雄,许曼音. 脂联素抵抗研究进展[J]. 国际内分泌代谢杂志, 2009, 29(3). DOI: 10.3760/cma.j.issn.1673-4157.2009.03.019 |
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| 作者姓名： | 林家煜 施亚雄 许曼音 |
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| 作者单位： | 福建医科大学附属第二医院内分泌科,泉州,362000;上海交通大学医学院附属瑞金医院内分泌代谢病科,200025 |
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| 摘 要： | 脂联素与脂联素受体结合,经多种信号转导途径发挥改善胰岛素抵抗、调节糖脂代谢、负性调控炎性反应以及拮抗动脉粥样硬化的作用.一些病理牛理过程中脂联素水平升高,但没有显著保护性效应,提示存在脂联素抵抗.脂联素抵抗的机制包括脂联素聚合能力改变、脂联素受体(AdipoRs)表达减少及脂联素受体后AMP活化蛋白激酶(AMPK)、过氧化物酶体增殖物活化受体(PPAR)α等信号通路转导障碍.高血糖、肥胖、胰岛素抵抗等与脂联素抵抗密切相关,可以互为因果,形成恶性循环.
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| 关 键 词： | 脂联素 受体 信号转导 脂联素抵抗 |
Research progress in adiponectin resistance |
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| LIN Jia-yu,SHI Ya-xiong,XU Man-yin. Research progress in adiponectin resistance[J]. International JOurnal of Endocrinology and Metabolism, 2009, 29(3). DOI: 10.3760/cma.j.issn.1673-4157.2009.03.019 |
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| Authors: | LIN Jia-yu SHI Ya-xiong XU Man-yin |
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| Abstract: | Adiponectin call improve insulin sensitivity,shcose and lipid metabolism and exert antiinflammatory and antiatherogenic effects by binding to its receptors,leading to activation of some signaling pathways.Hyperadiponectinaemia is found in some pathophysiological processes,without significant protective effect,which indicates the existence of adiponectin resistance.Mechanism of adiponectin resistance may include impaired multimerization of adiponectin mutants.down regulation of adiponectin receptors(AdipoRs) expression and deterioration of postreceptor signaling via AMP activated protein kinase(AMPK)and peroxisome proliferator activated receptor(PPAR) α activation.Hyperglycemia,obesity,and insulin resistance are closely related to adiponectin resistance.They may be a reciprocal causation and form a vicious circle. |
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| Keywords: | Adiponeetin Receptor Signal transduction Adiponectin resistance |
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