| 大孔吸附树脂分离纯化甘草酸的研究 |
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| 引用本文： | 郭永谊,贾艳艳,陈华. 大孔吸附树脂分离纯化甘草酸的研究[J]. 亚太传统医药, 2011, 7(11): 15-17 |
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| 作者姓名： | 郭永谊 贾艳艳 陈华 |
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| 作者单位： | 1. 中山大学附属第五医院,广东珠海,519000
2. 上海泛植制药有限公司,上海,201612 |
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| 摘 要： | 目的:用大孔吸附树脂对甘草酸进行分离纯化研究。方法:采用2001-5型、D141型、D130型、HPD-600型、HPD-100型5种大孔吸附树脂对甘草酸粗品进行吸附纯化,以甘草酸收率、纯度为考察指标综合评价,选择最佳纯化工艺。结果:HPD-600型大孔吸附树脂综合性能最好,其工艺条件为吸附流速2BV/h,pH值6.2,甘草酸水溶液浓度10mg/mL(甘草酸粗品/体积),用60%乙醇洗脱,甘草酸纯度可达95.02%。结论:HPD-600型大孔吸附树脂适合于甘草酸粗品的分离纯化。
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| 关 键 词： | 甘草酸 大孔吸附树脂 分离 纯化 |
Study on Separation and Purification of Glycyrrhizic Acid with Macroporous Adsorption Resins |
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| Guo Yongyi,Jia Yanyan,Chen Hua. Study on Separation and Purification of Glycyrrhizic Acid with Macroporous Adsorption Resins[J]. Asia-Pacific Traditional Medicine, 2011, 7(11): 15-17 |
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| Authors: | Guo Yongyi Jia Yanyan Chen Hua |
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| Affiliation: | Guo Yongyi1,Jia Yanyan1,Chen Hua2(1.Pharmacy of the Fifth Affiliated Hospital of Sun Yat-Sen University,Zhuhai 519000,China,2.Fan Zhi Pharmaceutical Co.Ltd.of Shanghai,Shanghai 201612,China) |
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| Abstract: | Objective:To explore an optimal method for separating and purifying glycyrrhizic acid with macroporous adsorption resins.Methods:2001-5,D141,D130,HPD-600 and HPD-100 types of macroporous adsorption resins were used to separate and purify glycyrrhizic acid.The adsorption ration,the elution ration,product purity and yields were compared.Results:HPD-600 macroporous adsorption resin showed better comprehensive adsorption property.The optimum operations were as follows:the current velocity was 2BV/h,pH of the sa... |
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| Keywords: | Glycyrrhizic Acid Macroporous Adsorption Resin Separation Puritication |
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