| L－精氨酸对氧化型低密度脂蛋白抑制内皮依赖性血管舒张的保护作用 |
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| 引用本文： | 李玉洁,李年生,游杰美,李元建. L－精氨酸对氧化型低密度脂蛋白抑制内皮依赖性血管舒张的保护作用[J]. 中国药理学与毒理学杂志, 1995, 0(3) |
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| 作者姓名： | 李玉洁 李年生 游杰美 李元建 |
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| 作者单位： | 湖南医科大学药理学教研室 |
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| 摘 要： | 在离体家兔胸主动脉环观察了Ｌ－精氦酸对氧化型低密度脂蛋白（ｏｘ－ＬＤＬ）和溶血磷脂酞胆碱（ＬＰＣ）抑制内皮依赖性血管舒张的保护作用。ｏｘ－ＬＤＬ（蛋白质含量０．４ｇ·Ｌ－１）和ＬＰＣ（４ｍｇ·Ｌ－１）均显著抑制乙酰胆碱的舒血管效应；Ｌ－精氨酸能减轻ｏｘ－ＬＤＬ和ＬＰＣ的抑制作用，并呈现剂量依赖性。这些结果提示，Ｌ－精氨酸对ｏｘ－ＬＤＬ所致血管内皮损伤具有保护作用。其机理可能与促进内皮细胞合成，释放一氧化氮有关。
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| 关 键 词： | 精氨酸；溶血磷脂酰胆碱关；脂蛋白类，低密度；主动脉，胸 |
Protection of L-arginine against attenuated endothelium-dependent vasorelaxation due to oxidizedlow-density lipoprotein 1 |
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| LI Yu-Jie, LI Nian-Sheng, YOU Jie-Mei, LI Yuan-Jian. Protection of L-arginine against attenuated endothelium-dependent vasorelaxation due to oxidizedlow-density lipoprotein 1[J]. Chinese Journal of Pharmacology and Toxicology, 1995, 0(3) |
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| Authors: | LI Yu-Jie LI Nian-Sheng YOU Jie-Mei LI Yuan-Jian |
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| Affiliation: | LI Yu-Jie, LI Nian-Sheng, YOU Jie-Mei, LI Yuan-Jian 2 |
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| Abstract: | The protective effect of Larginine on inhi-bition of endothelium-dependent vasorelaxation induced byoxidized lowdensity lipoprotein (ox-LDL) was investigatedin the isolated rabbit thoracic aorta. Vasodilator responsesto acetylcholine were impaired in the presence of ox-LDL(protein content 0.4 g· L-1) or lysophosphatidylcholine(LPC, 4 mg· L-1), a major component of ox-LDL.L-Arginine significantly attenuated the inhibition ofendotheliumdependent vasorelaxation induced by bothox-LDL and LPC in a concentrationdependent manner.These results suggest that Larginine may possess a protec-tion of the endothelium against damages elicited byox-LDL, and that the effect of L-arginine may be relatedto the facilitation of synthesis and/or release of nitricoxide. |
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| Keywords: | arginine Iysophosphatidylcholines lipoproteins low density aorta thoracic |
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