Maintenance of immunological memory: a role for CD5+ B cells? |
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| Authors: | F UytdeHaag R van der Heijden A Osterhaus |
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| Affiliation: | Laboratory of Immunobiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands. |
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| Abstract: | How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrogate antigen, selecting and stimulating emerging antigen-specific lymphocytes. |
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