Proto-oncogene c-fos is transiently induced in the rat cerebral cortex after forebrain ischemia |
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| Authors: | H Onodera K Kogure Y Ono K Igarashi Y Kiyota A Nagaoka |
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| Affiliation: | Department of Neurology, Tohoku University School of Medicine, Sendai, Japan. |
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| Abstract: | The amounts of mRNAs for proto-oncogene c-fos and structural protein beta-actin were measured in the rat cerebral cortex after transient forebrain ischemia. A transient and specific induction of c-fos mRNA was noticed in the cerebral cortex 30-90 min after ischemia followed by decline to control value. In contrast, the level of mRNA for beta-actin was not altered throughout the recirculation period examined. These results suggest specific role of c-fos gene after brain damage. |
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