| T－2毒素对培养软骨细胞生长代谢的作用 |
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| 引用本文： | 曹峻岭,熊咏民,张矢远.T－2毒素对培养软骨细胞生长代谢的作用[J].中国地方病学杂志,1994(5). |
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| 作者姓名： | 曹峻岭 熊咏民 张矢远 |
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| 作者单位： | 西安医科大学地方性骨病研究所 |
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| 基金项目： | ＂八五＂重点计划攻关课题 |
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| 摘 要： | 报告了Ｔ－２毒素对培养软骨细胞生长代谢的作用。结果显示，在软骨细胞生长早期和旺盛时期，Ｔ－２毒素抑制细胞ＤＮＡ合成，影响软骨细胞的分裂增殖，同时也影响到细胞的代谢功能，其毒性作用随Ｔ－２浓度升高细胞损伤加重。对于较成熟的软骨细胞，其毒性作用不明显。
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| 关 键 词： | T－2毒素，培养软骨细胞，大骨节病 |
Effect of T-2 Toxin on the growth and metabolism of cultural chondrocytes |
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| Cao Junling, Xiong Yongmin, Zhang Shiyuan.Effect of T-2 Toxin on the growth and metabolism of cultural chondrocytes[J].Chinese Jouranl of Endemiology,1994(5). |
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| Authors: | Cao Junling Xiong Yongmin Zhang Shiyuan |
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| Abstract: | In this paper, the effects of T-2 toxin on the growth and metabolism of cultural chondrocytes were reported. The result showed that the T-2 toxin restrains the DNA synthesis, and affects the division and growth of chondrocytes at the early and exuberant stage of the growth, meanwhile,affects the function of metabolism; that the higher the concentration of T-2 toxinin in the media,the more damage to the chondrocytes; that the toxicity seemed not to affect mature chondrocytes. |
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| Keywords: | T-2 toxin Cultural chondrocyte Kashin-Beck Disease |
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