三倍量(0.3mmol/kg)国产Gd-DTPA增强MR探查脑膜转移瘤的研究

目的 评价三倍量（０．３ｍｍｏｌ／ｋｇ）国产Ｇｄ－ＤＴＰＡ增强ＭＲ探查脑膜转移瘤的效果。材料与方法 用国产Ｇｄ－ＤＴＰＡ三倍量增强ＭＲ检查１１０例临床怀疑脑转移瘤患者。先行平扫，然后静脉注射常规量（０．１ｍｍｏｌ／ｋｇ）国产Ｇｄ－ＤＴＰＡ。注射后即刻行Ｔ１ＷＩ扫描，２０分钟后行延迟扫描。距第１次注射３０分钟后，再注射０．２ｍｍｏｌ／ｋｇ的Ｇｄ－ＤＴＰＡ，从而达到累积剂量０．３ｍｍｏｌ／ｋｇ。第２次

Evaluation of the Detection of Meningeal Metastases with Triple-dose Home-made Gd-DTPA Enhanced MR

Objective To evaluate triple dose home made Gd DTPA enhanced MR scanning in detecting meningeal metastases.Materials and Methods Triple dose home made Gd DTPA enhanced MR scanning was performed in 110 patients suspicious of brain metastases. After plain scan, routine dose of home made Gd DTPA (0.1 mmol/kg) was intravenously injected. T 1WI was obtained immediately and 20 minutes after the injection. Additional 0.2 mmol/kg of Gd DTPA was given at 30 minutes after the first injection, thus, the cumulative dose was up to 0.3 mmol/kg. T 1WI was obtained immediately and 20 minutes after the injection as described above. Fifteen patients underwent lumbar puncture for CSF cytology. MR findings were analyzed and compared with CSF results.Results Of 70 cases confirmed with intracranial metastases, 38 had meningeal metastases with total 70 meningeal lesions. On T 1WI with triple dose 33 more leptomeningeal lesions were detected than on T 1WI with routine dose. More abnormal meningeal lesions were found in 20 cases (20/70, 28.6%) on triple dose images, while the qualitative diagnosis was changed by triple dose images in 13 cases (13/70, 18.6%). Quantitative analysis of 70 lesions in 38 patients demonstrated an increase in relative signal intensity (C/N) when compared with routine dose studies (6.10/11.37,P<0.05).Conclusion Triple dose (0.3 mmol/kg) home made Gd DTPA enhanced MR scanning can improve the detactable rate of meningeal metastases.