| 小儿肾病患者肾组织病毒基因表达及临床意义 |
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| 引用本文： | 马路,周柱亮,杨琪,颜妍. 小儿肾病患者肾组织病毒基因表达及临床意义[J]. 中国中西医结合肾病杂志, 2001, 2(2): 88-90 |
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| 作者姓名： | 马路 周柱亮 杨琪 颜妍 |
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| 作者单位： | 北戴河281医院北京军区肾脏病中心,北戴河,066105 |
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| 基金项目： | “九五”全军青年基金资助项目 (No .A970 17) |
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| 摘 要： | 目的：探讨病毒感染在小儿肾脏病发病中的致病作用及临床意义。方法：应用聚合酶链反应（PCR）检测了224例小儿肾病患血清及肾活检组织中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、EB病毒（EBV）和巨细胞病毒（CMV）基因表达情况。结果：小儿肾病患血清和肾组织中HVB DNA检出阳性率分别为21.4%和19.6%；HCVRNA阳性率为4.0%和3.1%；EBVDNA阳性率为1.8%和0.5%；CMV DNA阳性率为0.9%和0.5%。结论：HBV感染在小儿肾脏疾病发病因素上起着重要的作用，HCV感染与小儿肾病的关系尚不明确，而EBV和CMV感染导致小儿肾病比较罕见。
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| 关 键 词： | 乙型肝炎病毒 丙型肝炎病毒 肾脏疾病 聚合酶链反应 EB病毒 巨细胞病毒 儿童 病毒感染 基因表达 |
| 修稿时间： | 2000-11-30 |
Detection of hepatitis B virus DNA and hepatitis C virus RNA in kidneys of nephropathy with children |
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| MA Lu,ZHOU Zhuliang,YANG Qi,YAN Yan. Detection of hepatitis B virus DNA and hepatitis C virus RNA in kidneys of nephropathy with children[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2001, 2(2): 88-90 |
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| Authors: | MA Lu ZHOU Zhuliang YANG Qi YAN Yan |
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| Abstract: | Objective:In order to know the pathogenetic mechanism of virus infection in nephropathy of children.Methods:HBV DNA,HCV RNA,EBV DNA and CMV DNA were detected in the sera and renal tissue of 224 patients using a polymerase chain reaction (PCR).Results:The positive rate of HBV DNA in the sera and renal tissue was 21.4% and 19.6% respectively;HCV RNA was 4.0% and 3.1%;EBV DNA was 1.8% and 0.5%;CMV DNA was 0.9% and 0.5%.Conclusion:Infection of HBV play a significantly action on the etiology of nephropathy in children.The corelation between infection of HCV and nephropathy is not defined nowadays,but pathogenetic mechanism of nephropathy in children may not related to the infection of EBV and CMV. |
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| Keywords: | Hepatitis B virus Hepatitis C virus Nephropathy Children Polymerase chain reaction |
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