| 三七丹参对大鼠免疫性肝纤维化的影响 |
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| 引用本文： | 李武,段丽芳,何贵清,杨海秋,黄学惠. 三七丹参对大鼠免疫性肝纤维化的影响[J]. 中药药理与临床, 2008, 24(6) |
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| 作者姓名： | 李武 段丽芳 何贵清 杨海秋 黄学惠 |
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| 作者单位： | 昆明医学院第一附属医院,昆明,650032 |
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| 基金项目： | 云南省教育厅基金项目:5Z0337C |
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| 摘 要： | 目的:观察三七丹参片抗大鼠免疫性肝纤维化的作用.方法:利用猪血清腹腔注射法复制大鼠免疫性肝纤维化模型,同时给予0.5、1、2 g/kg的三七丹参灌胃治疗6周.分离血清,检测肝功能,透明质酸(HA),Ⅲ型前胶原(PC-Ⅲ),Ⅳ型胶原云南省教育厅基金项目:520337C.(Ⅳ-C),层粘蛋白(LN).取肝组织病理检查,进行肝纤维化程度分期.结果:三七丹参能降低血清转氨酶,减轻肝纤维化程度,降低免疫性肝纤维化大鼠HA、LN、PCⅢ、Ⅳ-C水平,改善肝纤维化病变.结论:三七丹参具有抗肝纤维化作用.
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| 关 键 词： | 三七丹参 肝纤维化 免疫性 |
Effects of Sanqidanshen Tablet(三七丹参片) against immune liver fibrosis induced by porcine scrum in rats |
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| Li Wu,Duan Lifang,He Guiqing,Yang Haiqiu,Huang Xuehui. Effects of Sanqidanshen Tablet(三七丹参片) against immune liver fibrosis induced by porcine scrum in rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2008, 24(6) |
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| Authors: | Li Wu Duan Lifang He Guiqing Yang Haiqiu Huang Xuehui |
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| Affiliation: | Li Wu,Duan Lifang,He Guiqing,Yang Haiqiu,Huang XuehuiDepartment of Infectious Disease,The First Affiliated Hospital of Kunming Medical University,Kunming 650032) |
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| Abstract: | Objective:To investigate the protective effect of Sanqidanshen tablet against immune liver fibrosis induced by porcine serum in rats.Methods:The experimental immune liver fibrosis model was produced by intraperitoneal injection porcine serum for 12 w in rats.From the 7th week after injection of porcine serum,Sanqidanshen tablet(0.5,1,2 g/kg)or colchicine(0.1 mg/kg)were administered intragastrically once a day for 6 w.All animals were sacrificed on the end of 12th week.The hepatic function was evaluated by d... |
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