基于静息态功能磁共振技术研究针灸调节病理状态的进展

查阅运用静息态功能磁共振(fMRI)技术探讨针灸调节病理状态的研究文献,分析针灸效应中枢作用机制的研究情况,结果表明:1针刺机制研究较之于灸法机制研究,数量上稍多,质量稍高;2研究主要集中于针刺镇痛,针刺镇痛的中枢机制已经初步定位于针刺对"疼痛矩阵"脑区和疼痛相关默认网络的靶向性调节,而针灸其它效应的中枢机制尚处于探索之中;3研究方案中多选用单一穴位,较少关注穴位配伍。故建议今后关于静息态fMRI与针灸机制相关的研究需加强灸法应用的中枢机制探讨,考虑与临床实际治疗方案一致的研究设计。

Development of Researches on Acupuncture Stimulation-induced Regulatory Effect under Pathological State Based on Resting-state Functional Magnetic Resonance Technology

Using keywords of"acupuncture,fMRI and resting state",authors of the present paper retrieved papers in both Chinese and English from CNKI and PubMed databases without time limitation.A total of 13articles(11for acupuncture and2 for moxibustion)met the standards were subjected to analysis.Of the 13 papers,6involve acupuncture analgesia,2moxibustion analgesia,3mild cognitive impairment,one involves stroke,and the rest one is for depression.Research results of acupuncture analgesia revealed that the analgesic effect is closely related to its regulation on"pain matrix"brain regions and pain-related default mode network.In the studies,a single acupoint is often used,without acupoints-combined recipes.Therefore,it is highly recommended that researchers pay more attention to1 studies on the underlying mechanism of moxibustion,and2 improvement of design protocols targeting requirements of acupuncture clinical practice.