从针刺降压动物实验研究试述针灸基础研究与临床转化

针灸基础研究是针灸医学的重要组成部分,也是促进针灸临床实践的动力。针灸治疗高血压具有悠久的历史,相应基础研究也在不断深入,但其有效性一直存在争议。本文从动物模型、穴位选择、刺激参数、机制研究4个方面总结针刺降压的动物实验研究现状,发现针灸降压基础研究和临床实践之间脱节明显,不能在穴位选择、刺激参数等方面很好地指导临床实践。据此本文探讨如何架设针灸基础研究和临床实践的转化桥梁,认为针灸临床实践中存在问题是基础研究的立脚点,除揭示针灸作用的机制外,促进针灸基础研究成果向临床转化也应作为终极目标,两者共同实现针灸从验证疗效到提高疗效的飞跃,促进针灸医学的健康发展。

Our Considerations about Basic Research and Clinical Translation Based on Experimental Studies on Acupuncture-induced Blood-pressure Reduction

Basic research is an important component of acupuncture medicine,and is also the driving force for improving clinical practice.Acupuncture therapy has been used to treat hypertension for many years in China,and its underlying mechanism has also been progressively and partially explored,but its therapeutic effect remains controversial.Authors of the present paper summarize the current state of experimental researches on acupuncture treatment of hypertension from the establishment of hypertension model,acupoint selection,stimulation parameters,and related action mechanisms,and simultaneously found a disassociation between the basic research and clinical practice,particularly in the selection of acupoints and stimulation parameters.Therefore,to establish a bridge for better translation from many achievements of experimental studies to clinical application is of great practical significance.The authors hold that the existing problems of clinical practice should be the foothold of basic research,while successful transformation from basic research achievements to clinical practice is our ultimate target.Only in this way,can we incessantly achieve the goal of improving clinical therapeutic effect of acupuncture therapy from the phase of effectiveness verification,and promote the healthy development of acupuncturology.