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| 血液灌流清除体内免疫复合物的实验研究 | |
| 引用本文： | 于美丽,贾克培,吕文岚,杨彦,郭贤权.血液灌流清除体内免疫复合物的实验研究[J].中国生物医学工程学报,2001,20(1):12-16. |
| 作者姓名： | 于美丽 贾克培 吕文岚 杨彦 郭贤权 |
| 作者单位： | 1. 天津市第三中心医院, 2. 南开大学分子生物学研究所, 3. 南开大学高分子化学研究所, |
| 摘 要： | 本文从5种亲和吸剂（Affinity Absorbent,AA)中筛选出对病理性循环免疫复合物（Cycle Immune Complex,CIC)具有特异性吸附的吸附剂AA3，测定其孔结构参数，讨论了不同吸附条件对吸附性能的影响。用纯种大白兔作为实验动物，建立高特环免疫动物模型，用AA3吸附剂对运动模型进行血液灌流实验，观察该吸附剂血灌流清除血中CIC的功效。考察了AA3吸附剂的血液相容性及对蛋白的影响。实验结果表明AA3吸附剂对血中CIC的吸附率达41.７％，动物模型血灌流对ＣＩＣ的吸附率达３８.4%。 |
| 关 键 词： | 亲和吸附剂 循环免疫复合物 血液灌流 血液相容性 血液净化 |
| 修稿时间： | 1997年10月9日 |
EXPERIMENTAL STUDY ON HEMOPERFUSION REMOVAL OF CIRCULAR IMMUNE COMPLEX IN SERUM |
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| Yu Meili,Jia Kepei,Lui Wenlan,Yang Yan,GUO Xianquan.EXPERIMENTAL STUDY ON HEMOPERFUSION REMOVAL OF CIRCULAR IMMUNE COMPLEX IN SERUM[J].Chinese Journal of Biomedical Engineering,2001,20(1):12-16. | |
| Authors: | Yu Meili Jia Kepei Lui Wenlan Yang Yan GUO Xianquan |
| Institution: | Yu Meili,Jia Kepei,Lui Wenlan,Yang Yan1,Guo Xianquan2 |
| Abstract: | We selected an affinity absorbent (AA 3) from 5 kinds of absorbents. The AA 3 was a specific absorbent of pathologic circular immune complex (CIC). The physical properties of the absorbents were determinated. The factors that affected the absorption of CIC were discussed. The rabbit model of high CIC concentration were established and AA 3 affinity absorbent to remove CIC in serum were studied. The results showed that the removal rate of CIC was 41.7% in the serum and 38.4% in the model of hemoperfusion. The blood compatibility was also investigated. |
| Keywords: | Circular immune complex (CIC) Affinity absorbent Hemoperfision Blood compatibility |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |